52 for selective serotonin reuptake inhibitors (SSRIs)

In the United States pandora rings, however, the application for approval was ultimately rejected after preliminary acceptance.2 4Compared with the overall amount of antidepressants prescribed, reboxetine’s share is relatively small. For example, of 974 million defined daily doses of antidepressants prescribed in Germany in 2008, reboxetine accounted for 6.7 million defined daily doses.5 The average cost of reboxetine per defined daily dose was 1.87 (1.54; $2.39) for Edronax (Pfizer, Berlin) to 2.09 for Solvex (Merz, Frankfurt), compared with 0.52 for selective serotonin reuptake inhibitors (SSRIs), the most commonly prescribed antidepressants.5Although reboxetine has been claimed to show superior efficacy to placebo and similar efficacy to other antidepressants,1 6 7 8 9 10 the clinical relevance of the drug has been queried. A recent systematic review by Cipriani et al11 included a network meta analysis of active controlled trials and found that reboxetine was not only significantly less effective than the other newer antidepressants investigated, but was also the drug with the highest dropout rates.The German Institute for Quality and Efficiency in Health Care (Institut fr Qualitt und Wirtschaftlichkeit im Gesundheitswesen (IQWiG)) conducted a health technology assessment of the short term and long term benefits and harms of reboxetine, bupropion, and mirtazapine in placebo controlled and active controlled trials of adult patients with major depressive disorder.

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